Vaccine Research Process
Multiple steps are involved in the process of creating new therapeutic cancer vaccines. At the CVC, there is coordination of effort and ongoing communication among scientists and clinicians. Laboratory and clinical research activities lead to the evaluation of new vaccine candidates in human clinical trials. Vaccine discovery and design activities include:
- Large-scale target screening through bioinformatics and structural biology
- Tumor sample profiling through tissue typing, gene expression, SNP arrays, CGHA, proteoarrays, MS/MS proteomics
- In vitro target validation, including epitope mapping, cytokine profiling, MS/MS proteomics
- Vaccine formulation and design through bioinformatics, structural biology, targeted experimentation and nanoparticles
- Priming and challenge of mouse models
- Human cohort trials
