Recent findings of scientific and clinical significance at the CVC are published below. Additional relevant literature by CVC staff may be found by the author's name at:

Recent Publications:

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For publications prior to 2005, please contact us.

TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells. Immunity.
Kobayashi N, Karisola P, Peña-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ. December 2007. View Web Site
Mixed hematopoietic chimerism for sickle cell disease prevents intravascular hemolysis.  Br J Haematol, 139(3): 504-7.
Wu CJ, Gladwin M, Tisdale J, Hsieh M, Biernacki M, Rogers S, Wang X, Walters M, Zahrieh D, Antin JH, Ritz J, Krishnamurti L. December 2007.
Immunoinformatics. Springer, NY, USA, ISBN: 0387729674.
Schonbach C, Ranganathan S, Brusic V (editors). November 2007.
Evolutionarily conserved protein sequences of influenza A viruses, avian and human, as vaccine targets. PLoS ONE 2(11), e1190.
Heiny AT, Miotto O, Srinivasan KN, Khan AM, Zhang GL, Brusic V, Tan TW, August JT. November 2007. View Web Site
Predicting peptides binding to MHC class II molecules using multi-objective evolutionary algorithms. BMC Bioinformatics 8(1), 459.
Rajapakse M, Schmidt B, Feng L, Brusic V. November 2007. View Web Site
Understanding prediction systems for HLA-binding peptides and T-cell epitope identification. Lecture Notes in Bioinformatics 4774, 337-348.
You L, Zhang P, Boden M, Brusic V. October 2007.
Quantitative monitoring by polymerase colony assay of known mutations resistant to ABL kinase inhibitors. Oncogene, in press.
Nardi V, Raz T, Cao X, Wu CJ, Stone R, Cortes J, Deininger M, Church G, Zhu J, Daley GQ. October 2007.
Target discovery using proteomic microarrays. BIOforum Europe, 11(10), 20-22.
Marina O, Wu CJ, Brusic V. October 2007.
High levels of B cell activating factor (BAFF) in patients with active chronic graft versus host disease. Clin Cancer Res, 13, 6107-6114.
Sarantopoulo, S, Stevenson KE, Kim HT, Bhuiya NS, Cutler CS, Soiffer RJ, Antin JH, Ritz J. October 2007. View Web Site
Excision repair cross-complementation group 1 predicts progression-free and overall survival in non-small cell lung cancer patients treated with platinum-based chemotherapy. Cancer Science, 98(9):1336-43.
Azuma K, Komohara Y, Sasada T, Terazaki Y, Ikeda J, Hoshino T, Itoh K,Yamada A, Aizawa H. September 2007. View Web Site
CTL recognition of a protective immunodominant influenza A virus nucleoprotein epitope utilizes a highly restricted Vbeta but diverse Valpha repertoire: functional and structural implications. J Mol Biol. 372:535-548.
Zhong W, Dixit SB, Mallis RJ, Lugovskoy AA, Beveridge DL, Wagner G, Reinherz EL. September 2007. View Web Site
Long-term T cell memory to human leucocyte antigen-A2 supertype epitopes in humans vaccinated against smallpox. Clin Exper Immunol 149(2), 265-73.
Ostrout ND, McHugh MM, Tisch DJ, Moormann AM, Brusic V, Kazura JW. August 2007. View Web Site
Major neutralizing sites on vaccinia virus glycoprotein B5 are exposed differently on variola virus ortholog B6. J Virol. 81:8131-8139
Aldaz-Carroll L, Xiao Y, Whitbeck JC, de Leon MP, Lou H, Kim M, Yu J, Reinherz EL, Isaacs SN, Eisenberg RJ, Cohen GH. August 2007. View Web Site
In silico characterization of immunogenic epitopes presented by HLA-Cw*0401. Immunome Res 3(1), 7.
Tong JC, Zhang ZH, August JT, Brusic V, Tan TW, Ranganathan S. August 2007. View Web Site
Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of beta cells. Blood 110(3), 954-61.
Enzler T, Gillessen S, Dougan M, Allison JP, Neuberg D, Oble DA, Mihm M, Dranoff G. August 2007. View Web Site
Functional role for IkBNS in T cell cytokine regulation as revealed by targeted gene disruption. J Immunol. 179:1681-1692
Touma M, Antonini V, Kumar M, Osborn SL, Bobenchik AM, Keskin DB, Connolly JE, Grusby MJ, Reinherz EL, Clayton LK. August 2007. View Web Site
MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF. J Clin Invest 117(7),1902-13.
Jinushi M, Nakazaki Y, Dougan M, Carrasco DR, Mihm M, Dranoff G. July 2007. View Web Site
Increased levels of IgG antibodies against peptides of the prostate stem cell antigen in the plasma of pancreatic cancer patients. Oncol Rep 18(1), 161-6.
Tanaka M, Komatsu N, Terakawa N, Yanagimoto Y, Oka M, Sasada T, Mine T, Gouhara S, Shichijo S, Okuda S, Itoh K. July 2007. View Web Site
Impact of cytogenetics on outcome of de novo and therapy-related AML and MDS after allogeneic transplantation. Biol Blood Marrow Transplant 13, 655-664.
Armand P, Kim HT, DeAngelo DJ, Ho VT, Cutler CS, Stone RM, Ritz J, Alyea EP, Antin JH, Soiffer RJ. June 2007.
Z39Ig is expressed on macrophages and may mediate inflammatory reactions in arthritis and atherosclerosis. J Leukoc Biol 80(4), 922-8.
Lee MY, Kim WJ, Kang YJ, Jung YM, Kang YM, Suk K, Park JE, Choi EM, Choi BK, Kwon BS, Lee WH. June 2007.
Characterization of ABL1 expression in adult T-cell acute lymphoblastic leukemia by oligonucleotide array analysis. Haematologica 92, 619-626.
Chiaretti S, Tavolaro S, Ghia EM, Ariola C, Matteucci C, Elia L, Maggio R, Messina M, Ricciardi MR, Vitale A, Ritz J, Mecucci C, Guarini A, Foà R. May 2007.
Nanoparticles of poly(lactide)-tocopheryl polyethylene glycol succinate (PLA-TPGS) copolymers for protein drug delivery, Biomaterials 28(11), 2041-50.
Lee S.H., Zhang Z.P., Feng S.S. April 2007. View Web Site
New peptide vaccine candidates for epithelial cancer patients with HLA-A3 supertype alleles. J Immunother 30(3), 274-281.
Matsueda S, Takedatsu H, Sasada T, Azuma K, Ishihara Y, Komohara Y, Noguchi M, Shichijo S, Itoh K, Harada M. April 2007.
Folate Decorated Poly(lactide-co-glycolide)-Vitamin E TPGS Nanoparticles for Targeted Drug Delivery, Biomaterials 28 (10), 1889-1899.
Zhang Z.P., Lee S.H., Feng S.S. April 2007. View Web Site
Prediction of supertype-specific HLA class I binding peptides using support vector machines. J Immunol Methods 320(1-2):143-54.
Zhang GL, Bozic I, Kwoh CK, August JT, Brusic V. March 2007. View Web Site
The growth of bioinformatics (editorial). Brief Bioinform 8(2), 69-70.
Brusic V. March 2007.
Proteome informatics for cancer research: From molecules to clinic. Proteomics 7(6), 976-991.
Brusic V, Marina O, Wu CJ, Reinherz EL. March 2007.
Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis. Blood 109, 2001-2007.
Bellucci R, Oertelt S, Gallagher M, Li S, Zorn E, Weller E, Porcheray F, Alyea EP, Soiffer RJ, Munshi NC, Gershwin ME, Ritz J. March 2007.
Beyond HLA: The significance of genomic variation for allogeneic hematopoietic stem cell transplantation. Blood 109, 1355-1362.
Mullally A, Ritz J. February 2007.

Information for Patients

The CVC is developing new, disease-specific cancer vaccines by working closely with individual programs at DFCI.