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 Tools    >> Rankpep: Prediction of peptide binding to MHC molecules
Description
This server predicts MHCI- and MHCII-peptide binders from protein sequence or sequence alignments using Position Specific Scoring Matrices (PSSMs). In addition, it predicts those MHCI ligands whith a C-terminal end is that likely to be the result of proteasomal cleavage. A detailed explanation of the method can be found here.
PSSM
SELECT PSSM (Check MHCI or MHCII)
MHC I MHC II
OR, UPLOAD YOUR PSSM
INPUT
TYPE: FASTA sequence/s CLUSTALW multiple sequence alignment
Replace sample with your query
OR, UPLOAD SEQUENCES
BINDING THRESHOLD
PERCENTAGE: TOP NUMBER:
PROTEASOME
CLEAVAGE
FILTER: LMPC :
If Filter is ON only peptides predicted to be cleaved are shown
ADVANCED OPTONS
RESTRICT RESULTS BY MW
Lower Limit for Molecular Weight
Upper Limit for Molecular Weight
VARIABILITY MASKING

Select Variability Threshold
Value must range between 0.0 and 4.3


Citation: Reche PA, Glutting JP and Reinherz EL. Prediction of MHC Class I Binding Peptides Using Profile Motifs. Human Immunology 63, 701 709 (2002).
Questions, and suggestions to: Pedro Reche
Mirror Site at: Immunomedicine Group, Facultad de Medicina, Universidad Complutense de Madrid, SPAIN.
Hits since June/2002 Last updated:
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