PEPVAC

GENOME WIDE PREDICTION OF PROMISCOUS EPITOPES FOR VACCINE DESIGN
T-cell vaccines HLA-peptide binding HLA-coverage Proteosome Cleavage

Function:

PEPVAC is a tool aimed to the development of fully covering multi-epitope vaccines against pathogenic organisms based on genome wide predictions of promiscous MHCI-restricted epitopes.

Description:

T-cell epitopes are first anticipated based on their binding to HLA molecules using profile-matrices, and then filtered for immunoproteasomal cleavage using a probabilistic model. HLA molecules present many allelic variants with distinct peptides specificities, and thus peptide binding predictions are given for a selected set of HLA alleles covering a whole population including all major ethnities. These HLA alleles are grouped in sets (superantigenes) whose predicted binding peptides are largely overlapping. Only the peptides predicted to bind to all HLA alleles included in each superantigen set are selected as potential T-cell epitopes. Thus, indentification of these promiscous peptide binders allows to mininize the total number of predicted epitopes whithout compromising the population coverage required in the design of multi-epitope vaccines.
E-MAIL
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Enter your e-mail
GENOMES
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Select a genome
Upload genome (File with translated ORFs in FASTA format)
 
SUPERTYPES
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Select HLA-Supertype/s
A2: A*0201, A*0202, A*0203, A*0205, A*0206, A*0207, A6802
A3: A*0301, A*1101, A*3101, A*3301, A*6801, A*6601
A24: A*2402, B*3801
B7: B*0702, B*3501, B*5101, B*5102, B*5301, B*5401
B15: A*0101, B*1501_B62, B1502
Population Coverage with selected supertypes [help]
PROTEASOME CLEAVAGE
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Filter: Model:
For questions about this site, please contact Pedro Reche
Contact us: Bioinformatics Molecular Immunology Foundation